Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Bone marrow mesenchymal stromal cells (BM-MSCs) have anti-inflammatory and pro-
survival properties. Naturally, they do not express human leukocyte antigen class II surface …

Objective EndoC-βH5 is a newly established human beta-cell model which may be superior
to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely …

The hyperexpression of human leukocyte antigen class I (HLA-I) molecules on pancreatic
beta-cells is widely accepted as a hallmark feature of type 1 diabetes pathogenesis. This …

The propensity to develop type 2 diabetes (T2D) is known to have both environmental and
hereditary components. In those with a genetic predisposition to T2D, it is widely believed …

Pancreatic islet β-cells weaken under oxidative stress. In this study, human pancreatic islet-
derived 1.1 B4 cells were exposed to H2O2 and analysed using a human microarray, which …

Type 2 Diabetes and Alzheimer's Disease share many common features, including one
examined in this thesis: the build-up of proteins into toxic plaque in vital organs. The thesis …

Genome wide association studies (GWAS) revealed large numbers of variants that could
explain the heritability of type 2 diabetes (T2D). Since the majority of variants associated …

Loss of β-cell mass is a key mechanism leading to the development of Type 1 diabetes
(T1D). However, this process can be gradual with many patients retaining significant …

Background: The prevalence of diabetes has reached unprecedented rates worldwide.
Currently, 11.3% of the adult US population lives with diabetes, and 38% have prediabetes …