Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Metal toxicity links to Alzheimer's disease and neuroinflammation

TJ Huat, J Camats-Perna, EA Newcombe… - Journal of molecular …, 2019 - Elsevier
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Heavy metals exposure and Alzheimer's disease and related dementias

KM Bakulski, YA Seo, RC Hickman… - Journal of …, 2020 - content.iospress.com
Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

M Chin-Chan, J Navarro-Yepes… - Frontiers in cellular …, 2015 - frontiersin.org
Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain

V Karri, M Schuhmacher, V Kumar - Environmental toxicology and …, 2016 - Elsevier
Human exposure to toxic heavy metals is a global challenge. Concurrent exposure of heavy
metals, such as lead (Pb), cadmium (Cd), arsenic (As) and methylmercury (MeHg) are …

Molecular mechanism of arsenic-induced neurotoxicity including neuronal dysfunctions

M Thakur, M Rachamalla, S Niyogi… - International Journal of …, 2021 - mdpi.com
Arsenic is a key environmental toxicant having significant impacts on human health. Millions
of people in developing countries such as Bangladesh, Mexico, Taiwan, and India are …

Neurodegenerative and neurological disorders by small inhaled particles

HJ Heusinkveld, T Wahle, A Campbell, RHS Westerink… - Neurotoxicology, 2016 - Elsevier
The world⿿ s population is steadily ageing and as a result, health conditions related to
ageing, such as dementia, have become a major public health concern. In 2001, it was …

Health promoting properties of bee royal jelly: Food of the queens

N Collazo, M Carpena, B Nuñez-Estevez, P Otero… - Nutrients, 2021 - mdpi.com
Royal jelly (RJ) demand is growing every year and so is the market for functional foods in
general. RJ is formed by different substances, mainly carbohydrates, proteins, and lipids, but …

Environmental exposure to low-level lead (Pb) co-occurring with other neurotoxicants in early life and neurodevelopment of children.

JG Dórea - Environmental Research, 2019 - Elsevier
Lead (Pb) is a worldwide environmental contaminant that even at low levels influences brain
development and affects neurobehavior later in life; nevertheless it is only a small fraction of …