Fluorescence imaging of large-scale neural ensemble dynamics

TH Kim, MJ Schnitzer - Cell, 2022 - cell.com
Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

[HTML][HTML] Connectomic reconstruction predicts visual features used for navigation

D Garner, E Kind, JYH Lai, A Nern, A Zhao, L Houghton… - Nature, 2024 - nature.com
Many animals use visual information to navigate,,–, but how such information is encoded
and integrated by the navigation system remains incompletely understood. In Drosophila …

Optical volumetric brain imaging: speed, depth, and resolution enhancement

SH Huang, N Irawati, YF Chien, JY Lin… - Journal of Physics D …, 2021 - iopscience.iop.org
Understanding how the brain functions is one of the grand challenges in modern scientific
research. Similar to a computer, a functional brain is composed of hardware and software …

Layer 5 intratelencephalic neurons in the motor cortex stably encode skilled movement

T Shinotsuka, YR Tanaka, SI Terada… - Journal of …, 2023 - Soc Neuroscience
The primary motor cortex (M1) and the dorsal striatum play a critical role in motor learning
and the retention of learned behaviors. Motor representations of corticostriatal ensembles …

Two-photon image-scanning microscopy with SPAD array and blind image reconstruction

SV Koho, E Slenders, G Tortarolo… - Biomedical Optics …, 2020 - opg.optica.org
Two-photon excitation (2PE) laser scanning microscopy is the imaging modality of choice
when one desires to work with thick biological samples. However, its spatial resolution is …

Confocal Laser Scanning Microscopy Based on a Silicon Photomultiplier for Multicolor In Vivo Imaging in Near‐Infrared Regions I and II

T Yan, X Wang, S Liu, D Fan, X Xu, Q Zeng… - Small …, 2022 - Wiley Online Library
Confocal laser scanning microscopy (CLSM) is expected to exhibit a better imaging
performance in the second near‐infrared (NIR‐II) windows with weak tissue scattering and …

Ultrahigh-speed point scanning two-photon microscopy using high dynamic range silicon photomultipliers

VD Ching-Roa, EM Olson, SF Ibrahim, R Torres… - Scientific Reports, 2021 - nature.com
Conventional two-photon microscopes use photomultiplier tubes, which enable high
sensitivity but can detect relatively few photons per second, forcing longer pixel integration …

Pixelation with concentration-encoded effective photons for molecular optical sectioning microscopy

G Wang, RR Iyer, JE Sorrells, E Aksamitiene… - arXiv preprint arXiv …, 2023 - arxiv.org
Quality control in molecular optical sectioning microscopy is indispensable for transforming
acquired digital images from qualitative descriptions to quantitative data. Although …

High-sensitivity low-noise photodetector using a large-area silicon photomultiplier

T Masuda, A Hiramoto, DG Ang, C Meisenhelder… - Optics …, 2023 - opg.optica.org
The application of silicon photomultiplier (SiPM) technology for weak-light detection at a
single photon level has expanded thanks to its better photon detection efficiency in …

In Vivo Motility Patterns Displayed by Immune Cells Under Inflammatory Conditions

DU Pizzagalli, A Pulfer, M Thelen, R Krause… - Frontiers in …, 2022 - frontiersin.org
The migration of immune cells plays a key role in inflammation. This is evident in the fact that
inflammatory stimuli elicit a broad range of migration patterns in immune cells. Since these …