It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Obesity has reached epidemic proportions globally. Although modern adoption of a
sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause …

Abstract Development can be altered to match phenotypes with the environment, and the
genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated …

Precise dissection of DNA–protein interactions is essential for elucidating the recognition
basis, dynamics and gene regulation mechanism. However, global profiling of weak and …

Acute kidney injury (AKI) was previously thought to be a merely transient event; however,
recent epidemiological evidence supports the existence of a causal relationship between …

Highlights•Macrophage migration inhibitory factor (MIF) plays a crucial role in cancer and
inflammatory diseases.•Epigenetic mechanisms are involved in MIF-mediated …

Robotic high-throughput compound screening (HTS) and, increasingly, DNA-encoded
library (DEL) screening are driving bioactive chemical matter discovery in the postgenomic …

Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the
regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed …

Hepatocellular carcinoma (HCC), the most common liver malignancy with a poor prognosis
and increasing incidence, remains a serious health problem worldwide. Immunotherapy has …