Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …

Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

Here we describe the development of a human lung'small airway-on-a-chip'containing a
differentiated, mucociliary bronchiolar epithelium and an underlying microvascular …

Background: Chronic obstructive pulmonary disease (COPD) is characterised by both an
accelerated decline in lung function and periods of acute deterioration in symptoms termed …

Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD)
and reactive oxygen species (ROS) are able to alter biological molecules, signaling …

Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …

Inflammation is the body's response to insults, which include infection, trauma, and
hypersensitivity. The inflammatory response is complex and involves a variety of …

The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …