Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Background Lung infections are among the most consequential manifestations of cystic
fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs …

Two mycobacteriophages were administered intravenously to a male with treatment-
refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung …

Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

With the aging of population and the rapid improvement of public health and medical level in
recent years, people have had an increasing demand for orthopedic implants. However …

Standard doses of antibiotics do not efficiently treat chronic infections of the soft tissue and
bone. In this Personal View, we advocate for improving treatment of these infections by …

The ability to switch between different lifestyles allows bacterial pathogens to thrive in
diverse ecological niches,. However, a molecular understanding of their lifestyle changes …

Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …