Protozoan diseases continue to be a worldwide social and economic health problem.
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …

This review focuses on key components of respiratory and photosynthetic energy-
transduction systems: the cytochrome bc 1 and b 6 f (Cyt bc 1/b 6 f) membranous …

Lapachol is an abundant prenyl naphthoquinone occurring in Brazilian Bignoniaceae that
was clinically used, in former times, as an antimalarial drug, despite its moderate effect …

Natural products provide a vast array of chemical structures to explore in the discovery of
new medicines. Although secondary metabolites produced by microbes have been …

Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

The cytochrome bc1 complex is a key mitochondrial enzyme that catalyses transfer of
electrons maintaining the membrane potential of mitochondria. Currently, atovaquone is the …

Despite intense efforts, there has not been a truly new antimalarial, possessing a novel
mechanism of action, registered for over 10 years. By virtue of a novel mode of action, it is …

Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …

The Plasmodium mitochondrial electron transport chain has received considerable attention
as a potential target for new antimalarial drugs. Atovaquone, a potent inhibitor of …

The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …