The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and
intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role …

The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Acetyl-CoA, as an important molecule, not only participates in multiple intracellular
metabolic reactions, but also affects the post-translational modification of proteins, playing a …

The KEAP1/NRF2 pathway promotes metabolic rewiring to support redox homeostasis.
Activation of NRF2 occurs in many cancers, often due to KEAP1 mutations, and is …

In lung adenocarcinoma, oncogenic EGFR mutations co-occur with many tumor suppressor
gene alterations; however, the extent to which these contribute to tumor growth and …

The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …

Translocation renal cell carcinoma (tRCC) is a poorly characterized subtype of kidney
cancer driven by MiT/TFE gene fusions. Here, we define the landmarks of tRCC through an …