Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

The evolution of autophagy proteins–diversification in eukaryotes and potential ancestors in prokaryotes

S Zhang, Y Hama, N Mizushima - Journal of cell science, 2021 - journals.biologists.com
Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across
eukaryotes. Autophagy-related (ATG) genes have undergone extensive multiplications and …

Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation

Y Qiao, L Wang, T Hu, D Yin, H He, M He - Frontiers in pharmacology, 2021 - frontiersin.org
Background: The myocardium is susceptible to lipopolysaccharide (LPS)-induced damage
in sepsis, and cardiac dysfunction is a leading cause of mortality in patients with sepsis. The …

Apoptosis and autophagy: current understanding in tick–pathogen interactions

XR Wang, B Cull - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Tick-borne diseases are a significant threat to human and animal health throughout the
world. How tick-borne pathogens successfully infect and disseminate in both their vertebrate …

Mitochondrion-dependent apoptosis is essential for Rickettsia parkeri infection and replication in vector cells

XR Wang, NY Burkhardt, TJ Kurtti, JD Oliver, LD Price… - Msystems, 2021 - Am Soc Microbiol
Apoptosis is an innate immune response induced by infection in eukaryotes that contributes
significantly to protection from pathogens. However, little is known about the role of …

The role of autophagy in tick-endosymbiont interactions: insights from Ixodes scapularis and Rickettsia buchneri

XR Wang, B Cull, JD Oliver, TJ Kurtti… - Microbiology …, 2024 - Am Soc Microbiol
Approximately 80 identified tick species are recognized as vectors and impact global public
health by transmitting a wide range of pathogens; however, little is known about the …

Cat Flea Coinfection with Rickettsia felis and Rickettsia typhi

HJ Laukaitis-Yousey, KR Macaluso - Vector-Borne and Zoonotic …, 2024 - liebertpub.com
Purpose: Flea-borne rickettsioses, collectively referred to as a term for etiological agents
Rickettsia felis, Rickettsia typhi, and RFLOs (R. felis-like organisms), has become a public …

Immunostimulation of Parasteatoda tepidariorum (Araneae: Theridiidae) in juvenile and adult stages. Immunity reactions to injury with foreign body and Bacillus …

AE Czerwonka, MK Sawadro, J Brożek, AI Babczyńska - PeerJ, 2023 - peerj.com
To assess the immune potential of spiders, in the present study juvenile and adult females of
Parasteatoda tepidariorum were exposed to Bacillus subtilis infection, injury by a nylon …

Metabolic remodeling in arthropod embryonic cells under starvation

CL Nogueira, AF Arcanjo, ME Lima, B Moraes… - 2024 - researchsquare.com
In this study, we explore the adaptive mechanisms through which the tick Rhipicephalus
microplus can deal with a period of starvation, using as a model the BME26 cell line. Our …

The Significance of Rickettsia parkeri Outer Membrane Protein B in the Tick Host Infection and Autophagy

N Tongluan - 2023 - search.proquest.com
Rickettsia parkeri, a member of the spotted fever group Rickettsia, is a pathogen that can be
maintained and transmitted by Amblyomma maculatum. The geographic distribution of this …