[HTML][HTML] MicroRNA expression in β-thalassemia and sickle cell disease: a role in the induction of fetal hemoglobin
Today the regulatory role of microRNAs (miRs) is well characterized in many diverse cel-
lular processes. MiR-based regulation is categorized under epigenetic regulatory mecha …
lular processes. MiR-based regulation is categorized under epigenetic regulatory mecha …
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
B Wienert, APW Funnell, LJ Norton… - Nature …, 2015 - nature.com
Genetic disorders resulting from defects in the adult globin genes are among the most
common inherited diseases. Symptoms worsen from birth as fetal γ-globin expression is …
common inherited diseases. Symptoms worsen from birth as fetal γ-globin expression is …
Proteomics screening uncovers HMGA1 as a promising negative regulator for γ-globin expression in response to decreased β-globin levels
G Zhou, D Lu - Journal of Proteomics, 2023 - Elsevier
Reactivation of fetal hemoglobin (HbF) is a critical goal for the treatment of patients with
hemoglobinopathies. β-globin disorders can trigger stress erythropoiesis in red blood cells …
hemoglobinopathies. β-globin disorders can trigger stress erythropoiesis in red blood cells …
Krüppel-Like Factor 1 Gene Mutations in Thalassemia Patients from North Iran: Report of a New Mutation Associated with β-Thalassemia Intermedia
A Tamaddoni, S Khabaz Astaneh, R Tabaripour… - …, 2019 - Taylor & Francis
Thalassemia is a hereditary disease with an autosomal recessive inheritance pattern
resulting in reduced production of globin chains. Mutations in modifier genes can cause or …
resulting in reduced production of globin chains. Mutations in modifier genes can cause or …