Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
P van Oosten-Hawle - Frontiers in Physiology, 2023 - frontiersin.org
Aging results in a decline of cellular proteostasis capacity which culminates in the
accumulation of phototoxic material, causing the onset of age-related maladies and …
accumulation of phototoxic material, causing the onset of age-related maladies and …
[HTML][HTML] The mechanisms and roles of mitochondrial dynamics in C. elegans
D Campbell, S Zuryn - Seminars in Cell & Developmental Biology, 2024 - Elsevier
If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power
grid that regulates how that energy output is directed and maintained in response to unique …
grid that regulates how that energy output is directed and maintained in response to unique …
Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity
Accumulating evidence has demonstrated the presence of intertissue-communication
regulating systemic aging, but the underlying molecular network has not been fully explored …
regulating systemic aging, but the underlying molecular network has not been fully explored …
[HTML][HTML] Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans
LR Lapierre - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
The conserved autophagy transcription factor HLH-30/TFEB is a well-established modulator
of lifespan in several mechanistically-distinct longevity paradigms in C. elegans. While …
of lifespan in several mechanistically-distinct longevity paradigms in C. elegans. While …
Mitochondrial clearance and increased HSF-1 activity are coupled to promote longevity in fasted Caenorhabditis elegans
Fasting has emerged as a potent means of preserving tissue function with age in multiple
model organisms. However, our understanding of the relationship between food removal …
model organisms. However, our understanding of the relationship between food removal …
A Year at the Forefront of Proteostasis and Aging
MA Thompson, EA De-Souza - Biology Open, 2023 - journals.biologists.com
During aging, animals experience a decline in proteostasis activity, including loss of stress-
response activation, culminating in the accumulation of misfolded proteins and toxic …
response activation, culminating in the accumulation of misfolded proteins and toxic …
[HTML][HTML] DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans
A Johnson, C Ricaurte-Perez, P Wall… - Research …, 2024 - ncbi.nlm.nih.gov
Although life expectancy has increased, longer lifespans do not always align with prolonged
healthspans and, as a result, the occurrence of age-related degenerative diseases …
healthspans and, as a result, the occurrence of age-related degenerative diseases …
HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency
R Shalash, M Levi-Ferber, H von Chrzanowski… - bioRxiv, 2024 - biorxiv.org
The maintenance of a properly folded proteome is critical for cellular function and
organismal health, and its age-dependent collapse is associated with a wide range of …
organismal health, and its age-dependent collapse is associated with a wide range of …
Neuronal Control of Distal Mitochondrial Stress Responses and Their Impact on Metabolism
RJ Cornell - 2023 - bridges.monash.edu
Life is stressful, and so the ability to respond appropriately to physiological stress is an
essential skill for all living organisms. This thesis examines the mechanisms the brain uses …
essential skill for all living organisms. This thesis examines the mechanisms the brain uses …