The germinal centre B cell response to SARS-CoV-2
BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
T follicular helper cell biology: a decade of discovery and diseases
S Crotty - Immunity, 2019 - cell.com
Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
Antibody affinity shapes the choice between memory and germinal center B cell fates
C Viant, GHJ Weymar, A Escolano, S Chen… - Cell, 2020 - cell.com
Immunological memory is required for protection against repeated infections and is the basis
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
(GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6) …
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …
BAFF and BAFF-receptor in B cell selection and survival
CR Smulski, H Eibel - Frontiers in immunology, 2018 - frontiersin.org
The BAFF-receptor (BAFFR) is encoded by the TNFRSF13C gene and is one of the main pro-
survival receptors in B cells. Its function is impressively documented in humans by a …
survival receptors in B cells. Its function is impressively documented in humans by a …
[HTML][HTML] Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
I Quast, AR Dvorscek, C Pattaroni, TM Steiner… - Immunity, 2022 - cell.com
Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
T follicular helper cell-germinal center B cell interaction strength regulates entry into plasma cell or recycling germinal center cell fate
W Ise, K Fujii, K Shiroguchi, A Ito, K Kometani… - Immunity, 2018 - cell.com
Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …
recycling, respectively; however, how commitment to the plasma cell fate takes place is …