Shaping bacterial gene expression by physiological and proteome allocation constraints

M Scott, T Hwa - Nature Reviews Microbiology, 2023 - nature.com
Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

An ensemble approach to the structure-function problem in microbial communities

C Gopalakrishnappa, K Gowda, KH Prabhakara… - Iscience, 2022 - cell.com
The metabolic activity of microbial communities plays a primary role in the flow of essential
nutrients throughout the biosphere. Molecular genetics has revealed the metabolic …

Cell aggregation is associated with enzyme secretion strategies in marine polysaccharide-degrading bacteria

G D'Souza, A Ebrahimi, A Stubbusch… - The ISME …, 2023 - academic.oup.com
Polysaccharide breakdown by bacteria requires the activity of enzymes that degrade
polymers either intra-or extra-cellularly. The latter mechanism generates a localized pool of …

Changes in interactions over ecological time scales influence single-cell growth dynamics in a metabolically coupled marine microbial community

M Daniels, S van Vliet, M Ackermann - The ISME Journal, 2023 - academic.oup.com
Microbial communities thrive in almost all habitats on earth. Within these communities, cells
interact through the release and uptake of metabolites. These interactions can have …

[HTML][HTML] Bacterial growth in multicellular aggregates leads to the emergence of complex life cycles

JA Schwartzman, A Ebrahimi, G Chadwick, Y Sato… - Current Biology, 2022 - cell.com
Facultative multicellular behaviors expand the metabolic capacity and physiological
resilience of bacteria. Despite their ubiquity in nature, we lack an understanding of how …

Resource competition predicts assembly of in vitro gut bacterial communities

PY Ho, TH Nguyen, JM Sanchez, BC DeFelice… - biorxiv, 2022 - biorxiv.org
Members of microbial communities interact via a plethora of mechanisms, including
resource competition, cross-feeding, and pH modulation. However, the relative contributions …

A mutant fitness assay identifies bacterial interactions in a model ocean hot spot

JE Schreier, CB Smith, TR Ioerger… - Proceedings of the …, 2023 - National Acad Sciences
Bacteria that assemble in phycospheres surrounding living phytoplankton cells metabolize a
substantial proportion of ocean primary productivity. Yet the type and extent of interactions …

Interspecies interactions determine growth dynamics of biopolymer-degrading populations in microbial communities

G D'Souza, J Schwartzman… - Proceedings of the …, 2023 - National Acad Sciences
Microbial communities perform essential ecosystem functions such as the remineralization
of organic carbon that exists as biopolymers. The first step in mineralization is performed by …

Microbial invasion of a toxic medium is facilitated by a resident community but inhibited as the community co-evolves

P Piccardi, G Alberti, JM Alexander, S Mitri - The ISME Journal, 2022 - academic.oup.com
Predicting whether microbial invaders will colonize an environment is critical for managing
natural and engineered ecosystems, and controlling infectious disease. Invaders often face …

A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties

P Nanda, J Barrere, T LaBar, AW Murray - Current Biology, 2024 - cell.com
Cell division without cell separation produces multicellular clusters in budding yeast. Two
fundamental characteristics of these clusters are their size (the number of cells per cluster) …