From the 1Mayo Clinic, Jacksonville, Florida, 2Yale University School of Medicine, New
Haven, Connecticut, 3Cleveland Clinic Lerner College of Medicine of Case Western …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Background: Even on optimal therapy, many patients with heart failure and atrial fibrillation
experience cardiovascular complications. Additional treatments are needed to reduce these …

Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains
difficult and AF-related complications cause unacceptable morbidity and mortality even on …

Aims A strategy of systematic, early rhythm control (ERC) improves cardiovascular outcomes
in patients with atrial fibrillation (AF). It is not known how this outcome-reducing effect is …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an
annual increase of 5 million cases. Most AF patients have an established form of an atrial …

BACKGROUND Genomic and experimental studies suggest a role for PITX2 in atrial
fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested …

Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias detected by continuous rhythm
monitoring by pacemakers, defibrillators, or implantable cardiac monitors. Atrial high-rate …

In contrast to current guidelines and earlier trials, recent studies demonstrated superiority of
rhythm-over rate-control and challenged the strategy of" rate versus rhythm" therapy in …