Connexins in cancer: bridging the gap to the clinic

T Aasen, E Leithe, SV Graham, P Kameritsch… - Oncogene, 2019 - nature.com
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application

JI Wu, LH Wang - Journal of biomedical science, 2019 - Springer
Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer

Y Zou, S Fineberg, A Pearlman, RD Feinman, EJ Fine - PloS one, 2020 - journals.plos.org
Background The effects of diet in cancer, in general, and breast cancer in particular, are not
well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream …

Advances in rodent models for breast cancer formation, progression, and therapeutic testing

C Liu, P Wu, A Zhang, X Mao - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is a highly complicated disease. Advancement in the treatment and
prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and …

Connexin's connection in breast cancer growth and progression

D Banerjee - International journal of cell biology, 2016 - Wiley Online Library
Gap junctions are cell‐to‐cell junctions that are located in the basolateral surface of two
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …

Connexin 43, breast cancer tumor suppressor: Missed connections?

CL Grek, JM Rhett, JS Bruce, GS Ghatnekar, ES Yeh - Cancer letters, 2016 - Elsevier
Connexins are a family of transmembrane proteins that are characterized by their capacity to
form intercellular channels called gap junctions that directly link the cytoplasm of adjacent …

Connexin 43 in the development and progression of breast cancer: What's the connection?

SL Phillips, CB Williams… - International …, 2017 - spandidos-publications.com
Connexin 43 is a prominent gap junction protein within normal human breast tissue. Thus
far, there have been a number of research studies performed to determine the function of …

RGD-functionalised melanin nanoparticles for intraoperative photoacoustic imaging-guided breast cancer surgery

JJ Liu, Z Wang, LM Nie, YY Zhu, G Li, LL Lin… - European Journal of …, 2022 - Springer
Purpose Obtaining tumour-free margins is critical for avoiding re-excision and reducing local
recurrence following breast-conserving surgery; however, it remains challenging. Imaging …

Mapping the Anti-Cancer Activity of α-Connexin Carboxyl-Terminal (aCT1) Peptide in Resistant HER2+ Breast Cancer

KM Baker, M Abt, EH Doud, AL Oblak, ES Yeh - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer is a leading cause of death for women worldwide. This study
aims to examine the mechanisms for the anti-cancer effects of a therapeutic peptide agent …

[HTML][HTML] Cardiac to cancer: connecting connexins to clinical opportunity

CL Grek, JM Rhett, GS Ghatnekar - FEBS letters, 2014 - Elsevier
Gap junctions and their connexin components are indispensable in mediating the cellular
coordination required for tissue and organ homeostasis. The critical nature of their existence …