Wnt signaling is one of the key signaling pathways that govern numerous physiological
activities such as growth, differentiation and migration during development and …

Lipoplexes and polyplexes, electrostatic complexes between a plasmid DNA and cationic
lipids or polymers are chemical systems that are developed for gene delivery. Considerable …

Objective—The atheroprotective effects of estrogen are independent of circulating lipid
levels. Whether estrogen regulates transcytosis of LDL (low-density lipoprotein) across the …

Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease. Several genes have been associated with familial type PD, providing tremendous …

Extensive research is currently performed on designing safe and efficient non-viral carriers
for gene delivery. To increase their efficiency, it is essential to have a thorough …

Anaplastic lymphoma kinase–positive large B-cell lymphoma (ALK+ LBCL) is a rare,
aggressive subtype of diffuse large B-cell lymphoma with characteristic ALK …

Parkinson's disease (PD) is a common chronic and progressive neurodegenerative
disorder. Although the cause of PD is still poorly understood, mutations in many genes …

Large Ca transients cause massive endocytosis (MEND) in BHK fibroblasts by nonclassical
mechanisms. We present evidence that MEND depends on mitochondrial permeability …

Compensatory endocytosis (CE) ensures recycling of membrane components and
maintenance of plasma membrane size; however, the mechanisms, regulation, and …

The state-of-the art in water-soluble macromolecular therapeutics has been reviewed. First
the design principles for polymer-drug conjugates are discussed followed by two recent …