OBJECTIVE: Studies of the neurobiological processes underlying drug addiction primarily
have focused on limbic subcortical structures. Here the authors evaluated the role of frontal …

Understanding the changes in the brain which occur in the transition from normal to
addictive behavior has major implications in public health. Here we postulate that while …

Context In alcohol-dependent patients, brain atrophy and functional brain activation elicited
by alcohol-associated stimuli may predict relapse. However, to date, the interaction between …

Brain perfusion SPECT is a functional neuroimaging technique that allows noninvasive
study of physiologic and physiopathologic events in the human brain. With the appropriate …

BackgroundOrbitofrontal cortex dysfunctions have been frequently documented in people
with substance use disorders. The exact role of this cortical region, however, remains …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers.
Standardization of measurement conditions and correction for important modifiers is …

In this review, we highlight the role of neuroimaging techniques in studying the emotional
and cognitive-behavioral components of the addiction syndrome by focusing on the neural …

In humans, stroke or trauma-induced damage to the orbitofrontal cortex (OFC) or medial
prefrontal cortex (mPFC) results in impaired cognitive flexibility. Alcoholics also exhibit …

Investigations of neuropsychological functioning in alcoholism have revealed executive and
memory deficits which have been interpreted in the light of the “frontal lobe hypothesis” …