Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

O Palomares, M Martin-Fontecha, R Lauener… - Genes & …, 2014 - nature.com
The prevalence of allergic diseases has significantly increased in industrialized countries.
Allergen-specific immunotherapy (AIT) remains as the only curative treatment. The …

Clinical significance of miRNAs in autoimmunity

L Zhang, H Wu, M Zhao, C Chang, Q Lu - Journal of autoimmunity, 2020 - Elsevier
MicroRNAs (miRNAs) are evolutionally conserved, single-stranded RNAs that regulate gene
expression at the posttranscriptional level by disrupting translation. MiRNAs are key players …

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal …

E Ragni, A Papait, C Perucca Orfei… - Stem Cells …, 2021 - academic.oup.com
Human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) are easily
obtained in large quantities and free from ethical concerns. Promising therapeutic results for …

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Y Gao, J Tang, W Chen, Q Li, J Nie… - Proceedings of the …, 2015 - National Acad Sciences
Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune
homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells' signature and …

TGF‐β regulation of encephalitogenic and regulatory T cells in multiple sclerosis

PW Lee, ME Severin… - European journal of …, 2017 - Wiley Online Library
Transforming growth factor beta (TGF‐β) is a pleiotropic cytokine that has been shown to
influence the differentiation and function of T cells. The role that TGF‐β plays in immune …

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

N Araya, T Sato, H Ando, U Tomaru… - The Journal of …, 2014 - Am Soc Clin Investig
Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the
neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis …

miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Schistosome and Leishmania-associated Inflammation

S Kelada, P Sethupathy, IS Okoye, E Kistasis… - PLoS …, 2013 - journals.plos.org
A diverse suite of effector immune responses provide protection against various pathogens.
However, the array of effector responses must be immunologically regulated to limit …

Regulatory T cells in radiotherapeutic responses

D Schaue, MW Xie, JA Ratikan, WH McBride - Frontiers in Oncology, 2012 - frontiersin.org
Radiation therapy (RT) can extend its influence in cancer therapy beyond what can be
attributed to in-field cytotoxicity by modulating the immune system. While complex, these …

Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance

A Sethi, N Kulkarni, S Sonar, G Lal - Frontiers in genetics, 2013 - frontiersin.org
Gene expression is tightly regulated in a tuneable, cell-specific and time-dependent manner.
Recent advancement in epigenetics and non-coding RNA (ncRNA) revolutionized the …