[HTML][HTML] Drug discovery for chagas disease: A viewpoint
JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
F Altamura, R Rajesh, CMC CattaPreta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vectorborne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
Tissue tropism in parasitic diseases
S Silva Pereira, S Trindade, M De Niz… - Open …, 2019 - royalsocietypublishing.org
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major
cause of morbidity and mortality worldwide, but particularly in tropical, developing countries …
cause of morbidity and mortality worldwide, but particularly in tropical, developing countries …
[HTML][HTML] Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor
OJS Macleod, AD Cook, H Webb, M Crow… - Nature …, 2022 - nature.com
African trypanosomes are extracellular pathogens of mammals and are exposed to the
adaptive and innate immune systems. Trypanosomes evade the adaptive immune response …
adaptive and innate immune systems. Trypanosomes evade the adaptive immune response …
Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa,
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …
State-of-the-art in the drug discovery pathway for Chagas disease: A framework for drug development and target validation
JC Gabaldón-Figueira… - … and Reports in …, 2023 - Taylor & Francis
Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …
significant public health concern throughout the world. Development of new medications …
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets
M Laureano de Souza, TJWJD Lapierre… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …
[HTML][HTML] Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Introduction Cryptosporidiosis is a leading cause of diarrheal-associated morbidity and
mortality, predominantly affecting children under 5 years old in low-and-middle-income …
mortality, predominantly affecting children under 5 years old in low-and-middle-income …
Guidelines for the purification and characterization of extracellular vesicles of parasites
C FernandezBecerra, P Xander… - Journal of …, 2023 - Wiley Online Library
Parasites are responsible for the most neglected tropical diseases, affecting over a billion
people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible …
people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible …
Animal models of Chagas disease and their translational value to drug development
E Chatelain, I Scandale - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction American trypanosomiasis, better known as Chagas disease, is a global public
health issue. Current treatments targeting the causative parasite, Trypanosoma cruzi, are …
health issue. Current treatments targeting the causative parasite, Trypanosoma cruzi, are …