Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …
biochemically and genetically distinct from other forms of cell death and that has emerged to …
ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage
XH Ma, JHZ Liu, CY Liu, WY Sun, WJ Duan… - Signal transduction and …, 2022 - nature.com
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease
characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed …
characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed …
Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2
During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune
homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary …
homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary …
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves
important roles in physiology by sculpting complex tissues during embryogenesis and by …
important roles in physiology by sculpting complex tissues during embryogenesis and by …
The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases
High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …
functional phenotypes depending on environmental cues. Macrophages remain in balanced …
Lipid quality control and ferroptosis: from concept to mechanism
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …
The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism
Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …
Achieving life through death: redox biology of lipid peroxidation in ferroptosis
H Bayır, TS Anthonymuthu, YY Tyurina, SJ Patel… - Cell chemical …, 2020 - cell.com
Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions
leading to neuronal death, including programs of regulated death, are commonly viewed as …
leading to neuronal death, including programs of regulated death, are commonly viewed as …