The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

Background CD8+ T cells differentiate into exhausted status within tumors, including
hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor …

It has been proposed that the local segregation of kinases and the tyrosine phosphatase
CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs …

Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental
and clinical interest. Using quantitative interactomics, we define the composition and …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …

T cells possess an array of functional capabilities important for host defense against
pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR) …

T cells carry out the formidable task of identifying small numbers of foreign antigenic
peptides rapidly and specifically against a very noisy environmental background of …

T cells are critical components of adaptive immunity. As such, their activation is regulated by
the T cell receptor (TCR) that constantly scan peptides associated with major …