Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Antioxidant defence systems and oxidative stress in poultry biology: An update

PF Surai, II Kochish, VI Fisinin, MT Kidd - Antioxidants, 2019 - mdpi.com
Poultry in commercial settings are exposed to a range of stressors. A growing body of
information clearly indicates that excess ROS/RNS production and oxidative stress are …

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms

M Gade, N Comfort, DB Re - Environmental research, 2021 - Elsevier
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental
pollutants and are known to exert severe adverse impacts on the nervous system even at …

Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022 - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

[HTML][HTML] Selenium nanoparticles synthesized using an eco-friendly method: dye decolorization from aqueous solutions, cell viability, antioxidant, and antibacterial …

BA Al Jahdaly, NS Al-Radadi, GMG Eldin… - journal of materials …, 2021 - Elsevier
Selenium nanoparticles (SeNPs) were fabricated using a green microwave technique in the
presence of ascorbic acid. The morphological features indicated that the semi-spherical …

The role of the thioredoxin system in brain diseases

G Bjørklund, L Zou, M Peana, CT Chasapis, T Hangan… - Antioxidants, 2022 - mdpi.com
The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …

Cellular and molecular mechanisms mediating methylmercury neurotoxicity and neuroinflammation

JP Novo, B Martins, RS Raposo, FC Pereira… - International journal of …, 2021 - mdpi.com
Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir,
MeHg bioaccumulates along the food chain until it is consumed by riverine populations …

Progress in understanding ferroptosis and its targeting for therapeutic benefits in traumatic brain and spinal cord injuries

X Hu, Y Xu, H Xu, C Jin, H Zhang, H Su, Y Li… - Frontiers in cell and …, 2021 - frontiersin.org
Acute central nervous system (CNS) trauma, including spinal cord injury (SCI) and traumatic
brain injury (TBI), always leads to severe sensory, motor and autonomic nervous system …

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …

Mercury interactions with selenium and sulfur and the relevance of the Se: Hg molar ratio to fish consumption advice

M Gochfeld, J Burger - Environmental Science and Pollution Research, 2021 - Springer
Eating fish is often recommended as part of a healthful diet. However, fish, particularly large
predatory fish, can contain significant levels of the highly toxic methylmercury (MeHg) …