Transplantations of various stem cells or their progeny have repeatedly improved cardiac
performance in animal models of myocardial injury; however, the benefits observed in …

Following an insult by both intrinsic and extrinsic pathways, complex cellular, and molecular
interactions determine a successful recovery or inadequate repair of damaged tissue. The …

Background Identifying the mechanistic pathways potentially associated with incident heart
failure (HF) may provide a basis for novel preventive strategies. Methods and Results To …

Treatment with anti-TNF-α (tumor necrosis factor), one of the pivotal cytokines, was
introduced to clinical practice at the end of last century and revolutionized the treatment of …

Objective We sought to define the intrinsic stem cell capacity in pediatric heart lesions, and
the effects of diagnosis and of age, in order to inform evidence-based use of potential …

Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that
have acquired specific genetic abnormalities experience a selective advantage in vitro …

Background: Heart failure (HF) may arise from alterations in metabolic, structural, and
signaling pathways, but its genetic architecture is incompletely understood. To elucidate …

There is an increasing interest in understanding the connection between the immune and
cardiovascular systems, which are highly integrated and communicate through finely …

Heart failure (HF) is characterized by progressive fibrosis. Both fibroblasts and
mesenchymal stem cells (MSCs) can differentiate into pro-fibrotic myofibroblasts. MSCs …

Aging is associated with chronic systemic inflammation largely due to increased
myelopoiesis, which in turn increases risk for vascular disease. We have previously shown …