Overcoming the roadblocks to cardiac cell therapy using tissue engineering
Transplantations of various stem cells or their progeny have repeatedly improved cardiac
performance in animal models of myocardial injury; however, the benefits observed in …
performance in animal models of myocardial injury; however, the benefits observed in …
Three in a box: understanding cardiomyocyte, fibroblast, and innate immune cell interactions to orchestrate cardiac repair processes
Following an insult by both intrinsic and extrinsic pathways, complex cellular, and molecular
interactions determine a successful recovery or inadequate repair of damaged tissue. The …
interactions determine a successful recovery or inadequate repair of damaged tissue. The …
Proteomic bioprofiles and mechanistic pathways of progression to heart failure: the HOMAGE study
JP Ferreira, J Verdonschot, T Collier… - Circulation: Heart …, 2019 - Am Heart Assoc
Background Identifying the mechanistic pathways potentially associated with incident heart
failure (HF) may provide a basis for novel preventive strategies. Methods and Results To …
failure (HF) may provide a basis for novel preventive strategies. Methods and Results To …
Bimodal function of anti-TNF treatment: shall we be concerned about anti-TNF treatment in patients with rheumatoid arthritis and heart failure?
PJ Kotyla - International journal of molecular sciences, 2018 - mdpi.com
Treatment with anti-TNF-α (tumor necrosis factor), one of the pivotal cytokines, was
introduced to clinical practice at the end of last century and revolutionized the treatment of …
introduced to clinical practice at the end of last century and revolutionized the treatment of …
Cardiac regenerative capacity is age-and disease-dependent in childhood heart disease
A Traister, R Patel, A Huang, S Patel, J Plakhotnik… - PloS one, 2018 - journals.plos.org
Objective We sought to define the intrinsic stem cell capacity in pediatric heart lesions, and
the effects of diagnosis and of age, in order to inform evidence-based use of potential …
the effects of diagnosis and of age, in order to inform evidence-based use of potential …
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Y Lei, D Al Delbany, N Krivec, M Regin… - Stem Cell Reports, 2024 - cell.com
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that
have acquired specific genetic abnormalities experience a selective advantage in vitro …
have acquired specific genetic abnormalities experience a selective advantage in vitro …
Integrated multiomics approach to identify genetic underpinnings of heart failure and its echocardiographic precursors: Framingham heart study
Background: Heart failure (HF) may arise from alterations in metabolic, structural, and
signaling pathways, but its genetic architecture is incompletely understood. To elucidate …
signaling pathways, but its genetic architecture is incompletely understood. To elucidate …
Polarizing macrophage functional phenotype to foster cardiac regeneration
There is an increasing interest in understanding the connection between the immune and
cardiovascular systems, which are highly integrated and communicate through finely …
cardiovascular systems, which are highly integrated and communicate through finely …
Cardiac mesenchymal stem cells promote fibrosis and remodeling in heart failure: role of PDGF signaling
Heart failure (HF) is characterized by progressive fibrosis. Both fibroblasts and
mesenchymal stem cells (MSCs) can differentiate into pro-fibrotic myofibroblasts. MSCs …
mesenchymal stem cells (MSCs) can differentiate into pro-fibrotic myofibroblasts. MSCs …
Reversal of aging-associated increase in myelopoiesis and expression of alarmins by angiotensin-(1–7)
K Chittimalli, J Jahan, A Sakamuri, H Weyrick… - Scientific Reports, 2023 - nature.com
Aging is associated with chronic systemic inflammation largely due to increased
myelopoiesis, which in turn increases risk for vascular disease. We have previously shown …
myelopoiesis, which in turn increases risk for vascular disease. We have previously shown …