Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences

BL Daughtry, SL Chavez - Cell and tissue research, 2016 - Springer
Formation of a totipotent blastocyst capable of implantation is one of the first major
milestones in early mammalian embryogenesis, but less than half of in vitro fertilized …

[HTML][HTML] An overview of the available methods for morphological scoring of pre-implantation embryos in in vitro fertilization

N Nasiri, P Eftekhari-Yazdi - Cell Journal (Yakhteh), 2015 - ncbi.nlm.nih.gov
Assessment of embryo quality in order to choose the embryos that most likely result in
pregnancy is the critical goal in assisted reproductive technologies (ART). The current trend …

Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

SL Chavez, KE Loewke, J Han, F Moussavi… - Nature …, 2012 - nature.com
Previous studies have demonstrated that aneuploidy in human embryos is surprisingly
frequent with 50–80% of cleavage-stage human embryos carrying an abnormal …

Morphogenesis of the human preimplantation embryo: bringing mechanics to the clinics

J Firmin, JL Maître - Seminars in Cell & Developmental Biology, 2021 - Elsevier
During preimplantation development, the human embryo forms the blastocyst, the structure
enabling uterine implantation. The blastocyst consists of an epithelial envelope, the …

Cellular and molecular nature of fragmentation of human embryos

A Cecchele, GC Cermisoni, E Giacomini… - International Journal of …, 2022 - mdpi.com
Embryo fragmentation represents a phenomenon generally characterized by the presence
of membrane-bound extracellular cytoplasm into the perivitelline space. Recent evidence …

[HTML][HTML] Prediction of human blastocyst development from morulas with delayed and/or incomplete compaction

M Ivec, B Kovacic, V Vlaisavljevic - Fertility and sterility, 2011 - Elsevier
OBJECTIVE: To determine the influence of delayed compaction and fragmentation on the
developmental capacity of morulas. DESIGN: Prospective study. SETTING: University IVF …

[HTML][HTML] Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation

VY Fujimoto, RW Browne, MS Bloom, D Sakkas… - Fertility and …, 2011 - Elsevier
This narrative review summarizes the current state of knowledge about human embryo
fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence …

Ovarian hyperstimulation syndrome prevention strategies: cryopreservation of all embryos

A D'Angelo - Seminars in reproductive medicine, 2010 - thieme-connect.com
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic potentially life-threatening
condition resulting from excessive ovarian stimulation. The crucial event in the development …

[HTML][HTML] Fragmentation of embryos is associated with both necrosis and apoptosis

HJ Chi, JJ Koo, SY Choi, HJ Jeong, SI Roh - Fertility and sterility, 2011 - Elsevier
Objective To explore the association between embryo fragmentation and necrosis and
apoptosis. Design A prospective study. Setting Mizmedi Hospital. Patient (s) None …

Ultrastructure of cytoplasmic fragments in human cleavage stage embryos

I Halvaei, MA Khalili, N Esfandiari, S Safari… - Journal of assisted …, 2016 - Springer
Purpose The goal of this study was to evaluate the ultrastructure of cytoplasmic fragments
along with the effect of cytoplasmic fragment and perivitelline space coarse granulation …