Wnt signaling is activated by wounding and participates in every subsequent stage of the
healing process from the control of inflammation and programmed cell death, to the …

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation
and compose the complex nervous system. Wnt signaling is thought to control the balance of …

Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high
percentage of the population. Currently, no approach exists to obtain large numbers of …

Brain development is orchestrated by both innate and experience-dependent mechanisms,
but their relative contributions are difficult to disentangle. Here we asked if and how central …

Mammalian hair cells do not regenerate, and their loss is a major cause of deafness. We
recently identified leucine-rich repeat containing, G-protein-coupled receptor 5 (Lgr5) …

Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

Background The zebrafish retina maintains two populations of stem cells: first, the germinal
zone or ciliary marginal zone (CMZ) contains multipotent retinal progenitors that add cells to …

An effective healing response is critical to promote and ensure healthy aging. Major
discoveries in both fields—repair and aging—have led to a better understanding of the …

Progenitor cells in the central nervous system must leave the cell cycle to become neurons
and glia, but the signals that coordinate this transition remain largely unknown. We …

Purpose.: Müller glia respond to retinal injury by a reactive gliosis, but only rarely do
mammalian glial cells re-enter the cell cycle and generate new neurons. In the …