Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …

Proper cell cycle progression through the interphase and mitosis is regulated by coordinated
activation of important cell cycle proteins (including cyclin-dependent kinases and mitotic …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Abstract Polo-like kinase 1 (Plk1) is instrumental for mitotic entry and progression. Plk1 is
activated by phosphorylation on a conserved residue Thr210 in its activation segment by the …

This study aims to investigate the potential mechanisms and identify core biomarkers of
Hepatocellular carcinoma (HCC). The profile GSE113850 was downloaded to analyze the …

Wee1 kinase plays an important role in regulating G2/M checkpoint and S phase, and the
inhibition of it will lead to mitotic catastrophe in cancer cells with p53 mutation or deletion …

Hepatitis B virus X protein (HBx) contributes to Hepatitis B virus (HBV)-related liver cancer.
However, its impact on hepatocyte proliferation and genomic stability remains elusive. We …

Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic
entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 phase, but …

Abstract Cytoskeletal‑associated protein 2 (CKAP2), which is also known as tumor‑
associated microtubule‑associated protein, has been reported to be dysregulated in various …

Kv10. 1 (potassium voltage-gated channel subfamily H member 1, known as EAG1 or Ether-
à-go-go 1), is a voltage-gated potassium channel, prevailingly expressed in the central …