Human herpesviruses are large double-stranded DNA viruses belonging to the
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …

The use of genotypic resistance testing of herpes simplex virus types 1 and 2 (HSV-1 and
HSV-2) is increasing because the rapid availability of results significantly improves the …

Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in
allogeneic hematopoietic stem cell transplant recipients. The significant clinical impact of …

Background Cytomegalovirus (CMV) is a viral infection which establishes lifelong latency,
often reactivating and causing disease in immunosuppressed individuals, including …

Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing
concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is …

Abstract Herpes simplex virus 1 (HSV-1), a double-stranded DNA virus, replicates using
seven essential proteins encoded by its genome. Among these, the UL30 DNA polymerase …

The plaque reduction assay (PRA) is the gold standard phenotypic method to determine
herpes simplex virus (HSV) and human cytomegalovirus (HCMV) susceptibilities to antiviral …

DNA polymerases are important drug targets, and many structural studies have captured
them in distinct conformations. However, a detailed understanding of the impact of …

All herpesviruses encode a conserved DNA polymerase that is required for viral genome
replication and serves as an important therapeutic target. Currently available herpesvirus …

Amino acid substitutions conferring resistance of herpes simplex virus 1 (HSV-1) and human
cytomegalovirus (HCMV) to foscarnet (PFA) are located in the genes UL30 and UL54 …