The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and …

VE Glazier, J Kramara, T Ollinger, NV Solis… - MBio, 2023 - Am Soc Microbiol
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …

[HTML][HTML] Host immune response against fungal biofilms

M Mannan, S Nabeela, R Mishra, P Uppuluri - Current Opinion in …, 2024 - Elsevier
Highlights•Fungal biofilms are an attached community of cells enclosed in extracellular
polymeric matrix (ECM).•ECM hide fungal ligands and block phagocytosis, NETosis, and …

[HTML][HTML] The protective role of the Candida biofilm matrix in drug and immune protection

S Roy, NAR Gow - The Cell Surface, 2023 - Elsevier
Candida albicans, Candida auris and Candida tropicalis are three fungal pathogens that
WHO recently reported as requiring urgent attention and additional resources for research …

Cyclic strain of Poly (methyl methacrylate) surfaces triggered the pathogenicity of Candida albicans

C Montoya, J Kurylec, A Ossa, S Orrego - Acta Biomaterialia, 2023 - Elsevier
Candida albicans is an opportunistic yeast and the primary etiological factor in oral
candidiasis and denture stomatitis. The pathogenesis of C. albicans could be triggered by …

High-Throughput Screening of the Repurposing Hub Library to Identify Drugs with Novel Inhibitory Activity against Candida albicans and Candida auris Biofilms

OH Ajetunmobi, G Wall, B Vidal Bonifacio… - Journal of Fungi, 2023 - mdpi.com
Candidiasis is one of the most frequent nosocomial infections affecting an increasing
number of at-risk patients. Candida albicans remains the most frequent causative agent of …

Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in …

J Kramara, MJ Kim, TL Ollinger, LC Ristow… - mBio, 2024 - journals.asm.org
Protein kinases are critical regulatory proteins in both prokaryotes and eukaryotes.
Accordingly, protein kinases represent a common drug target for a wide range of human …

Candida albicans Biofilm-Derived Extracellular Vesicles Are Involved in the Tolerance to Caspofungin, Biofilm Detachment, and Fungal Proteolytic Activity

J Karkowska-Kuleta, K Kulig, G Bras, K Stelmaszczyk… - Journal of Fungi, 2023 - mdpi.com
It has been repeatedly reported that the cells of organisms in all kingdoms of life produce
nanometer-sized lipid membrane-enveloped extracellular vesicles (EVs), transporting and …

[HTML][HTML] The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral …

VE Glazier, J Kramara, T Ollinger, NV Solis… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …

Biofilm formation by the fungus Phaeomoniella chlamydospora: a causal agent of esca disease of grapevine

Z Karácsony, N Molnár, D Szabó, N Bakos-Barczi… - Mycological …, 2024 - Springer
The present study suggests that the Esca pathogenic fungus Phaeomoniella chlamydospora
can form biofilm in vitro and possibly in the grapevine host tissues. This phenomenon was …

SCRAPPY-a single cell rapid assay of proteome perturbation in yeast uncovers a joint role of aromatic amino acids and oxidative stress in the toxicity of lipophilic …

E Ghazy, VA Bidiuk, F Ryabov, OV Mitkevich… - bioRxiv, 2024 - biorxiv.org
Assaying cellular responses to antimicrobial molecules is a path to understanding modes of
action of potential drugs. This is often achieved via transcriptomics and proteomics, but …