The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

The stereoselectivity of glycosidic bond formation continues to pose a noteworthy hurdle in
synthesizing carbohydrates, primarily due to the simultaneous occurrence of SN1 and SN2 …

Abstract The stereoselective formation of 1, 2-cis glycosidic linkages is challenging. The
currently most widely used strategy for their installation uses 4, 6-O-benzylidene-protected …

A single acyloxy group at C‐2 can control the outcome of nucleophilic substitution reactions
of pyran‐derived acetals, but the extent of the neighboring‐group participation depends on a …

We herein reveal the possibility of the C-4 neighboring group/remote group participation
(NGP/RGP) facilitating the stabilization of the anomeric center via dioxolenium intermediates …

A combination of DFT calculations and experiments is used to describe how the selection of
a promoter can control the stereochemical outcome of glycosylation reactions with the deoxy …

Attaining complete anomeric control is still one of the biggest challenges in carbohydrate
chemistry. Glycosyl cations such as oxocarbenium and dioxanium ions are key …

When generated in a mass spectrometer bridged bicyclic 1, 3-dioxenium ions derived from 4-
O-acylgalactopyranosyl, donors can be observed by infrared spectroscopy at cryogenic …

Stereospecific α-glucosylation of primary and secondary OH-group at carbohydrate
acceptors is achieved using glucosyl N-phenyl-trifluoroacetimidate (PTFAI) donor protected …

One of the main challenges in oligosaccharide synthesis is the stereoselective introduction
of the glycosidic bond. In order to understand and control glycosylation reactions, thorough …