E3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation
system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) …

Multiple factors contribute to the development of connective tissue diseases (CTD), often
alongside a range of interstitial lung diseases (ILD), including Sjögren's syndrome …

Selective degradation of pathological protein aggregates while sparing monomeric forms is
of major therapeutic interest. The E3 ligase tripartite motif–containing protein 21 (TRIM21) …

Abstract Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus
spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as …

Myriad physiological and pathogenic processes are governed by protein levels and
modifications. Controlled protein activity perturbation is essential to studying protein function …

Parkinson's Disease (PD) is a chronic neurodegenerative disorder that impacts the
substantia niagra region of the midbrain leading to impaired motor as well as non-motor …

Tripartite motif‐containing protein 21 (TRIM21), identified as both a cytosolic E3 ubiquitin
ligase and FcR (Fragment crystallizable receptor), primarily interacts with proteins via its …

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a
hemorrhagic illness with high fatality rates in domestic pigs that has resulted in a substantial …

ABSTRACT Background and Objectives Tripartite motif-containing protein 50 (TRIM50) is a
recently discovered E3 ubiquitin ligase that participates in tumor progression. TRIM50 is …

Hijacking the ubiquitin proteasome system to elicit targeted protein degradation (TPD) has
emerged as a promising therapeutic strategy to target and destroy intracellular proteins at …