Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

BACKGROUND The nomenclature for patients with multiple injuries with high mortality rates
is highly variable, and there is a lack of a uniform definition of the term polytrauma. A …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient, which when implemented may improve patient outcomes …

Damage control resuscitation has become a topic of increasing relevance and popularity
over the past several years. Hemorrhage accounts for 30% to 40% of trauma fatalities and is …

Fat embolism (FE) occurs frequently after trauma and during orthopaedic procedures
involving manipulation of intramedullary contents. Classically characterized as a triad of …

Objectives Sustained changes in resuscitation and transfusion management have been
observed since the turn of the millennium, along with an ongoing discussion of surgical …

INTRODUCTION: Polytrauma patients represent the ultimate challenge to trauma care and
the optimisation of their care is a major focus of clinical and basic science research. A …