Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

Therapeutic antibodies are the largest class of biotherapeutics and have been successful in
treating human diseases. However, the design and discovery of antibody drugs remains …

Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

The electrocardiogram (ECG) empowered clinician scientists to measure the electrical
activity of the heart noninvasively to identify arrhythmias and heart disease. Shortly after the …

With growing concerns over the health impact of sugar, brazzein offers a viable alternative
due to its sweetness, thermostability, and low risk profile. Here, we demonstrated the ability …

In recent years, the widespread application of artificial intelligence algorithms in protein
structure, function prediction, and de novo protein design has significantly accelerated the …

The ability to design and synthesize proteins with specific functions holds great significance
for drug development, drug delivery, targeted therapy, and materials science. With the …

Protein engineering uses de novo protein design technology to change the protein gene
sequence, and then improve the physical and chemical properties of proteins. These newly …

The idea of using whole-cells as catalysts is intriguing, challenging, and a complex task.
While considering a particular production process involving the use of a cellular system as a …

Computational protein design, modeling, and Molecular Docking represent a group of vital
in-silico methods employed in predicting protein sequences with desired functions …