Background Paediatric patients are often exposed to subtherapeutic levels or treatment
failure of β-lactams, and prolonged infusion may be beneficial. We aimed to investigate the …

Objective To assess whether beta-lactam extended or continuous beta-lactam infusions
(EI/CI) improve clinical outcomes in children with proven or suspected bacterial infections …

Standard dosing could fail to achieve adequate systemic concentrations in ICU children or
may lead to toxicity in children with acute kidney injury. The population pharmacokinetic …

Purpose The aim of this study is to characterize the concentration-time profile,
pharmacokinetics parameters, and therapeutic target attainment of meropenem in pediatric …

Background: Preterm neonates rarely participate in clinical trials, this leads to lack of
adequate information on pharmacokinetics for most drugs in this population. Meropenem is …

Sensitive, precise, and fast differential pulse voltammetric (DPV) method has been
developed for determination of meropenem (MER) in pure form, pharmaceutical dosage …

Background Meropenem is a widely used carbapenem for treating severe pediatric
infections. However, few studies have assessed its pharmacokinetics/pharmacodynamics …