Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

In obese individuals, atherogenic dyslipidemia is a very common and important factor in the
increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized …

Background: The role of high-density lipoprotein (HDL) function in cardiovascular disease
represents an important emerging concept. The present study investigated whether HDL anti …

Background While several lines of evidence prove that elevated concentrations of low-
density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its …

Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an
inherent risk because inflammation can damage tissue and necrosis can provoke …

Lysophospholipids are a class of bioactive lipid molecules that produce their effects through
various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps …

Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P),
which maintains vascular integrity. We show that HDL-associated S1P is bound specifically …

Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …

The concept of raising high-density lipoprotein (HDL) has been the focus of increasing
attention as a strategy to reduce cardiovascular disease. HDL particles are, however, highly …

HDL cholesterol activates endothelial cell production of the atheroprotective signaling
molecule NO, and it promotes endothelial repair. In this issue of the JCI, Besler et al. provide …