Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are
all strongly associated and are all reaching epidemic proportions. Whether there is a causal …

Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell
types. Too many or too few LDs during excess or deficient fat storage lead to many different …

Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …

Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X)
have become global health epidemics. Over the past decade, the elucidation of key …

The worldwide epidemic of obesity and type 2 diabetes has greatly increased interest in the
biology and physiology of adipose tissues. Adipose (fat) cells are specialized for the storage …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and
accounts for many of its symptoms and complications, efforts to understand the …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …