Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Animal domestication has fascinated biologists since Charles Darwin first drew the parallel
between evolution via natural selection and human-mediated breeding of livestock and …

Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …

Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …

Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …

Although sled dogs are one of the most specialized groups of dogs, their origin and
evolution has received much less attention than many other dog groups. We applied a …

Viruses accumulate mutations under the influence of natural selection and host–virus
interactions. Through a systematic comparison of 351,525 full viral genome sequences …

Transmissible cancers, in which cancer cells themselves act as an infectious agent, have
been identified in Tasmanian devils, dogs, and four bivalves. We investigated a …

The premise of mutational signature analysis is that genomes acquire somatic mutations
through the collective action of discrete mutational processes, and its aim is to infer the …

Transmissible cancers are parasitic malignant cell lineages that have acquired the ability to
infect new hosts from the same species, or sometimes related species. First described in …