Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …

Purpose Cancer, a major public health problem, exhibits significant redox alteration.
Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting …

Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …

Targeting the redox balance of malignant cells via the delivery of high oxidative stress
unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …

Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …

Abstract Thioredoxin reductase 2 (TrxR2) is a key component of the mitochondrial
thioredoxin system able to transfer electrons to peroxiredoxin 3 (Prx3) in a reaction mediated …

Cancer cells are characterized by higher levels of reactive oxygen species (ROS) compared
to normal cells as a result of an imbalance between oxidants and antioxidants. However …

Gold (I) N‐heterocyclic carbene (AuI‐NHC) complexes have emerged as potential
anticancer agents owing to their high cytotoxicity and stability. Integration of their above …

Background Cancer cells from different origins exhibit various basal redox statuses and thus
respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics …