The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Abstract Background Selenium (Se) is not an essential element for plants, although it can
benefit their growth and survival in some envionments. Excess tissue Se concentrations are …

Glutathione peroxidase and thioredoxin reductase are major selenoenzymes through which
selenium exerts powerful antioxidant effects. Selenium also elicits pro-oxidant effects at toxic …

This review traces the discoveries that led to the recognition of selenium (Se) as an essential
nutrient and discusses Se-responsive diseases in animals and humans in the context of …

It is well known that oxidation caused by reactive oxygen species (ROS) is a major cause of
cellular damage and death and has been implicated in cancer, neurodegenerative, and …

Selenium (Se) is an essential trace element with a narrow margin between beneficial and
toxic effects. As a promising chemopreventive agent, its use requires consumption over the …

Reactive oxygen species (ROS) are derived from cellular oxygen metabolism and from
exogenous sources. An excess of ROS results in oxidative stress and may eventually cause …