The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Abstract Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central
transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance …

BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …