Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …

The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly
(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use …

The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double
hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S …

The human replisome is an elaborate arrangement of molecular machines responsible for
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …

Abstract CMG (Cdc45‐MCM‐GINS) helicase assembly at the replication origin is the
culmination of eukaryotic DNA replication initiation. This process can be reconstructed in …

Assembly of the CMG (CDC-45–MCM-2-7–GINS) helicase is the key regulated step during
eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require …

Faithful cell division is the basis for the propagation of life and DNA replication must be
precisely regulated. DNA replication stress is a prominent endogenous source of genome …

Despite large sequencing and data sharing efforts, previously characterized pathogenic
variants only account for a fraction of Mendelian disease patients, which highlights the need …