[HTML][HTML] Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses
MB Orr, JC Gensel - Neurotherapeutics, 2018 - Elsevier
Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …
are often focused on central nervous system (CNS) axon regeneration. However, secondary …
Cell transplantation therapy for spinal cord injury
Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …
[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
[HTML][HTML] Glial cells shape pathology and repair after spinal cord injury
Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …
correctly surmised that microglia in pathologic central nervous system (CNS) were …
Recent update on basic mechanisms of spinal cord injury
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …
250,000 and 500,000 individuals each year with an estimated two to three million people …
MicroRNAs: roles in regulating neuroinflammation
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …
physiological function in all multicellular organisms. Here, the role of miRNAs in …
Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation
C Wang, Q Wang, Y Lou, J Xu, Z Feng… - Journal of cellular …, 2018 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been
proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI …
proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI …
M1 and M2 immune activation in Parkinson's disease: foe and ally?
Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disorder of
unknown etiology. Autopsy findings, genetics, retrospective studies, and molecular imaging …
unknown etiology. Autopsy findings, genetics, retrospective studies, and molecular imaging …
Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives
JCT Chio, KJ Xu, P Popovich, S David… - Experimental …, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …
Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury
SF Ma, YJ Chen, JX Zhang, L Shen, R Wang… - Brain, behavior, and …, 2015 - Elsevier
Classically activated pro-inflammatory (M1) and alternatively activated anti-inflammatory
(M2) macrophages populate the local microenvironment after spinal cord injury (SCI). The …
(M2) macrophages populate the local microenvironment after spinal cord injury (SCI). The …