Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity.
To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries …

The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

Reactive oxygen species (ROS) derived from oxygen-dependent mitochondrial metabolism
are the essential drivers of cardiomyocyte (CM) cell-cycle arrest in adulthood. Mitochondria …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

Mitotic cells inactivate DNA double-strand break (DSB) repair, but the rationale behind this
suppression remains unknown. Here, we unravel how mitosis blocks DSB repair and …

Although molecular mechanisms that prompt cell-cycle arrest in response to DNA damage
have been elucidated, the systems-level properties of DNA damage checkpoints are not …

Gene tagging with fluorescent proteins is essential for investigations of the dynamic
properties of cellular proteins. CRISPR–Cas9 technology is a powerful tool for inserting …

In mitosis, cells inactivate DNA double-strand break (DSB) repair pathways to preserve
genome stability. However, some early signaling events still occur, such as recruitment of …