The ups and downs of alkyl‐carbamates in epilepsy therapy: how does cenobamate differ?

W Löscher, GJ Sills, HS White - Epilepsia, 2021 - Wiley Online Library
Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and
epilepsy, including meprobamate, flupirtine, felbamate, retigabine, carisbamate, and …

Neuropathic pain and Kv7 voltage-gated potassium channels: the potential role of Kv7 activators in the treatment of neuropathic pain

A Abd-Elsayed, M Jackson, SL Gu, K Fiala… - Molecular …, 2019 - journals.sagepub.com
Neuropathic pain conditions severely and chronically affect the quality of life in a large
human population, but the pain conditions are not adequately managed due to poor …

G-protein-gated inwardly rectifying potassium channels modulate respiratory depression by opioids

G Montandon, J Ren, NC Victoria, H Liu… - …, 2016 - pmc.ncbi.nlm.nih.gov
Background Drugs acting on μ-opioid receptors (MOR) are widely used as analgesics, but
present side-effects including life-threatening respiratory depression. MOR are G-protein …

Advances in targeting GIRK channels in disease

Y Zhao, I Gameiro-Ros, IW Glaaser… - Trends in pharmacological …, 2021 - cell.com
G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of
cell excitability in the brain. While they are implicated in a variety of neurological diseases in …

Flupirtine, a re-discovered drug, revisited

I Szelenyi - Inflammation Research, 2013 - Springer
Flupirtine was developed long before KV 7 (KCNQ) channels were known. However, it was
clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti …

Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice

P Huang, C Li, T Fu, D Zhao, Z Yi, Q Lu, L Guo… - Behavioural brain …, 2015 - Elsevier
Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-
dependent cognitive deficits. Flupirtine represents neuroprotective effects and we have …

Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain

Y Liu, X Bian, KW Wang - Pharmacology of Potassium Channels, 2021 - Springer
Native M-current is a low-threshold, slowly activating potassium current that exerts an
inhibitory control over neuronal excitability. The M-channel is primarily co-assembled by …

Pharmacological targeting of neuronal Kv7. 2/3 channels: a focus on chemotypes and receptor sites

F Miceli, MV Soldovieri, P Ambrosino… - Current medicinal …, 2018 - ingentaconnect.com
Background: The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5
members (Kv7. 1-5) each showing characteristic tissue distribution and physiological roles …

Failed, interrupted, or inconclusive trials on neuroprotective and neuroregenerative treatment strategies in multiple sclerosis: update 2015–2020

N Huntemann, L Rolfes, M Pawlitzki, T Ruck, S Pfeuffer… - Drugs, 2021 - Springer
In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

Neurobiology of organophosphate-induced seizures

J Williamson, T Singh, J Kapur - Epilepsy & behavior, 2019 - Elsevier
This review summarizes the efforts of our laboratories to develop a mechanism-based
therapy for the treatment of organophosphate (OP) nerve agent-induced seizures …