The ongoing challenge of latent tuberculosis

H Esmail, CE Barry 3rd, DB Young… - … Transactions of the …, 2014 - royalsocietypublishing.org
The global health community has set itself the task of eliminating tuberculosis (TB) as a
public health problem by 2050. Although progress has been made in global TB control, the …

Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis

G Mancuso, A Midiri, S De Gaetano, E Ponzo… - Microorganisms, 2023 - mdpi.com
Antibiotics have played a crucial role in the reduction in the incidence of TB globally as
evidenced by the fact that before the mid-20th century, the mortality rate within five years of …

[HTML][HTML] Mechanism investigation of ethosomes transdermal permeation

XQ Niu, DP Zhang, Q Bian, XF Feng, H Li… - International journal of …, 2019 - Elsevier
Ethosomes are widely used to promote transdermal permeation of both lipophilic and
hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin …

Self-clearance of Mycobacterium tuberculosis infection: implications for lifetime risk and population at-risk of tuberculosis disease

JC Emery, AS Richards, KD Dale… - … of the Royal …, 2021 - royalsocietypublishing.org
Background: it is widely assumed that individuals with Mycobacterium tuberculosis (Mtb)
infection remain at lifelong risk of tuberculosis (TB) disease. However, there is substantial …

Human immunology of tuberculosis

TJ Scriba, AK Coussens, HA Fletcher - Microbiology spectrum, 2017 - Am Soc Microbiol
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

Tuberculosis vaccines: time to think about the next generation

SHE Kaufmann - Seminars in immunology, 2013 - Elsevier
Efforts over the last 2 decades have led to a rich research and development pipeline of
tuberculosis (TB) vaccines. Although none of the candidates has successfully completed the …

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination

R Diel, R Loddenkemper, JP Zellweger… - European …, 2013 - Eur Respiratory Soc
The introduction of new rapid diagnostic tools for tuberculosis (TB) and the promising TB
drugs pipeline together with the development of a new World Health Organization Strategy …

Latent Mycobacterium tuberculosis Infection and Interferon-Gamma Release Assays

M Pai, M Behr - Microbiology spectrum, 2016 - Am Soc Microbiol
The identification of individuals with latent tuberculosis infection (LTBI) is useful for both
fundamental understanding of the pathogenesis of disease and for clinical and public health …

Management of tuberculosis infection: current situation, recent developments and operational challenges

G Agbota, M Bonnet, C Lienhardt - Pathogens, 2023 - mdpi.com
Tuberculosis infection (TBI) is defined as a state of infection in which individuals host live
Mycobacterium tuberculosis with or without clinical signs of active TB. It is now understood …

Innovative therapeutic approaches based on nanotechnology for the treatment and management of tuberculosis

P Kia, U Ruman, AR Pratiwi… - International journal of …, 2023 - Taylor & Francis
Tuberculosis (TB), derived from bacterium named Mycobacterium tuberculosis, has become
one of the worst infectious and contagious illnesses in the world after HIV/AIDS. Long-term …