The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic
S Broder - Antiviral research, 2010 - Elsevier
In the last 25 years, HIV-1, the retrovirus responsible for the acquired immunodeficiency
syndrome (AIDS), has gone from being an “inherently untreatable” infectious agent to one …
syndrome (AIDS), has gone from being an “inherently untreatable” infectious agent to one …
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine
T Cihlar, AS Ray - Antiviral research, 2010 - Elsevier
Twenty-five years ago, nucleoside analog 3′-azidothymidine (AZT) was shown to efficiently
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …
Impact of the Centers for Disease Control's HIV preexposure prophylaxis guidelines for men who have sex with men in the United States
SM Jenness, SM Goodreau… - The Journal of …, 2016 - academic.oup.com
Background Preexposure prophylaxis (PrEP) is effective for preventing human
immunodeficiency virus (HIV) infection among men who have sex with men (MSM) within …
immunodeficiency virus (HIV) infection among men who have sex with men (MSM) within …
The impact of patient race on clinical decisions related to prescribing HIV pre-exposure prophylaxis (PrEP): assumptions about sexual risk compensation and …
Antiretroviral pre-exposure prophylaxis (PrEP) has received increasing recognition as a
viable prescription-based intervention for people at risk for HIV acquisition. However, little is …
viable prescription-based intervention for people at risk for HIV acquisition. However, little is …
Development of a clinical screening index predictive of incident HIV infection among men who have sex with men in the United States
DK Smith, SL Pals, JH Herbst, S Shinde… - JAIDS Journal of …, 2012 - journals.lww.com
Background: To implement biomedical and other intensive HIV prevention interventions cost-
effectively, busy care providers need validated, rapid, risk screening tools for identifying …
effectively, busy care providers need validated, rapid, risk screening tools for identifying …
High interest in preexposure prophylaxis among men who have sex with men at risk for HIV infection: baseline data from the US PrEP demonstration project
SE Cohen, E Vittinghoff, O Bacon… - JAIDS Journal of …, 2015 - journals.lww.com
Background: Preexposure prophylaxis (PrEP) is the first biomedical intervention with proven
efficacy to reduce HIV acquisition in men who have sex with men (MSM) and transgender …
efficacy to reduce HIV acquisition in men who have sex with men (MSM) and transgender …
Current status and challenges of antiretroviral research and therapy
JA Esté, T Cihlar - Antiviral research, 2010 - Elsevier
Twenty-five years after the discovery of the therapeutic activity of azidothymidine (AZT), the
first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus …
first antiretroviral drug used in the clinic, infection with the human immunodeficiency virus …
The cost-effectiveness of preexposure prophylaxis for HIV prevention in the United States in men who have sex with men
JL Juusola, ML Brandeau, DK Owens… - Annals of internal …, 2012 - acpjournals.org
Background: A recent randomized, controlled trial showed that daily oral preexposure
chemoprophylaxis (PrEP) was effective for HIV prevention in men who have sex with men …
chemoprophylaxis (PrEP) was effective for HIV prevention in men who have sex with men …
The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies
Background Cost-effectiveness studies inform resource allocation, strategy, and policy
development. However, due to their complexity, dependence on assumptions made, and …
development. However, due to their complexity, dependence on assumptions made, and …
Limited awareness and low immediate uptake of pre-exposure prophylaxis among men who have sex with men using an internet social networking site
DS Krakower, MJ Mimiaga, JG Rosenberger… - PloS one, 2012 - journals.plos.org
Background In 2010, the iPrEx trial demonstrated that oral antiretroviral pre-exposure
prophylaxis (PrEP) reduced the risk of HIV acquisition among high-risk men who have sex …
prophylaxis (PrEP) reduced the risk of HIV acquisition among high-risk men who have sex …