[HTML][HTML] Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease

T Seike, CH Chen, D Mochly-Rosen - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Cleavage of Hsp70. 1 causes lysosomal cell death under stress conditions

T Yamashima, D Mochly-Rosen… - Frontiers in Molecular …, 2024 - frontiersin.org
Autophagy mediates the degradation of intracellular macromolecules and organelles within
lysosomes. There are three types of autophagy: macroautophagy, microautophagy, and …