Background Polysubstance use (PSU) is prevalent among individuals with substance use
disorders, but the vast majority of preclinical substance use research has focused on …

Childhood maltreatment has been suggested to have an adverse impact on
neurodevelopment, including microstructural brain abnormalities. Existing neuroimaging …

The dynorphin/kappa opioid receptor (KOR) system is implicated in the “dark side” of
addiction, in which stress exacerbates maladaptive responses to drug and alcohol …

Research on the inter-relationship between drug abuse and social stress has primarily
focused on the role of stress exposure during adulthood and more recently, adolescence …

Stress-related psychiatric conditions are one of the main causes of disability in developed
countries. They account for a large portion of resource investment in stress-related …

Background Experiencing traumatic childhood is a risk factor for developing substance use
disorder, but the mechanisms that underlie this relationship have not been determined …

Childhood maltreatment, including abuse and neglect, may have sustained effects on the
integrity and functioning of the brain, alter neurophysiological responsivity later in life, and …

Background: The current study aimed to test whether food addiction (FA) might mediate the
relationship between the presence of a history of childhood maltreatment and eating …

Background: Drug addiction is a complex brain disorder that is characterized by craving,
withdrawal, and relapse, which can be perpetuated by social stress. Stemming from an …

Objective One factor potentially contributing to the heterogeneity of previous results on
structural grey matter alterations in adult participants suffering from post‐traumatic stress …