Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system
C Fernandez-Antunez, K Wang, U Fahnøe… - Hepatology, 2023 - journals.lww.com
Conclusions: Baseline NS5A-RAS can compromise the efficacy of double-DAA
pangenotypic regimens for HCV genotype 3, and enhanced viral fitness can accelerate …
pangenotypic regimens for HCV genotype 3, and enhanced viral fitness can accelerate …
Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer
DG Gallinson, CP Kozakiewicz… - Proceedings of the …, 2024 - National Acad Sciences
Coevolution is common and frequently governs host–pathogen interaction outcomes.
Phenotypes underlying these interactions often manifest as the combined products of the …
Phenotypes underlying these interactions often manifest as the combined products of the …
The knowledge on HCV: from the discovery to the elimination
J Guan, Y Ren, J Wang, H Zhu - Infectious Microbes & Diseases, 2022 - journals.lww.com
From being described as “non-A, non-B” hepatitis in 1975 and being identified in 1989, to
the emergence of direct-acting antiviral drugs (DAAs), knowledge on hepatitis C virus (HCV) …
the emergence of direct-acting antiviral drugs (DAAs), knowledge on hepatitis C virus (HCV) …
An integrated machine learning framework for classification of cirrhosis, fibrosis, and hepatitis
Hepatitis C is an ailment that causes inflammation of the liver and leads to serious liver
damage. In previous research, the accuracy of the model wasn't that accurate but the …
damage. In previous research, the accuracy of the model wasn't that accurate but the …
Pre‐existing, treatment‐specific resistance‐associated substitutions in hepatitis C virus genotype 1 and 3 and viral RNA titers during treatment with direct‐acting …
C Sølund, MS Pedersen, U Fahnøe, J Filskov… - APMIS, 2023 - Wiley Online Library
The introduction of direct‐acting antiviral (DAA) treatment of hepatitis C virus (HCV) infected
patients has greatly increased treatment success rates. However, viral response kinetics to …
patients has greatly increased treatment success rates. However, viral response kinetics to …
Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study
B Flower, L Mccabe, MA Ansari, C Le Ngoc, TV Thi… - Elife, 2023 - elifesciences.org
Background: World Health Organization has called for research into predictive factors for
selecting persons who could be successfully treated with shorter durations of direct-acting …
selecting persons who could be successfully treated with shorter durations of direct-acting …
Full-length sequence analysis of hepatitis C virus genotype 3b strains and development of an in vivo infectious 3b cDNA clone
PS Bajpai, L Collignon, C Sølund, LW Madsen… - Journal of …, 2023 - Am Soc Microbiol
Worldwide, genotype 3 is the second most prevalent major variant among patients with
chronic hepatitis C virus (HCV) infection and the most difficult to treat with direct-acting …
chronic hepatitis C virus (HCV) infection and the most difficult to treat with direct-acting …
Viral genomic variation and the severity of genital HSV-2 infection as quantified by shedding rate: a viral genome-wide association study
Background The clinical severity of genital HSV-2 infection varies widely among infected
persons with some experiencing frequent genital lesions while others are asymptomatic …
persons with some experiencing frequent genital lesions while others are asymptomatic …
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
K Yamauchi, S Maekawa, L Osawa… - Journal of …, 2024 - Springer
Background Defective hepatitis C virus (HCV) genomes with deletion of the envelope region
have been occasionally reported by short-read sequencing analyses. However, the clinical …
have been occasionally reported by short-read sequencing analyses. However, the clinical …
Epidemiology of Hepatitis C Virus in HIV Patients from West Mexico: Implications for Controlling and Preventing Viral Hepatitis
A Jose-Abrego, ME Trujillo-Trujillo, S Laguna-Meraz… - Pathogens, 2024 - mdpi.com
The complex epidemiology of hepatitis C virus (HCV) infection among human
immunodeficiency virus (HIV) patients in West Mexico remains poorly understood. Thus, this …
immunodeficiency virus (HIV) patients in West Mexico remains poorly understood. Thus, this …