Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

E Haldón, MC Nicasio, PJ Pérez - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism, and applications

JR Johansson, T Beke-Somfai… - Chemical …, 2016 - ACS Publications
The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1, 5-disubstituted 1, 2,
3-triazoles in one step and complements the more established copper-catalyzed reaction …

The CuAAC: Principles, homogeneous and heterogeneous catalysts, and novel developments and applications

S Neumann, M Biewend, S Rana… - Macromolecular Rapid …, 2020 - Wiley Online Library
The copper‐catalyzed azide/alkyne cycloaddition reaction (CuAAC) has emerged as the
most useful “click” chemistry. Polymer science has profited enormously from CuAAC by its …

Transition metal-mediated synthesis of monocyclic aromatic heterocycles

AV Gulevich, AS Dudnik, N Chernyak… - Chemical …, 2013 - ACS Publications
Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …

Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

The copper (I)-catalyzed alkyne-azide cycloaddition (CuAAC)“click” reaction and its applications. An overview

L Liang, D Astruc - Coordination Chemistry Reviews, 2011 - Elsevier
A short overview of the copper (I)-catalyzed azide alkyne cycloaddition (CuAAC), the most
used “click” reaction, is presented, including the introduction of the “click” concept, the …

From mechanism to mouse: a tale of two bioorthogonal reactions

EM Sletten, CR Bertozzi - Accounts of chemical research, 2011 - ACS Publications
Bioorthogonal reactions are chemical reactions that neither interact with nor interfere with a
biological system. The participating functional groups must be inert to biological moieties …

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper (I) acetylides

JE Hein, VV Fokin - Chemical Society Reviews, 2010 - pubs.rsc.org
Copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a widely utilized, reliable, and
straightforward way for making covalent connections between building blocks containing …

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

EM Sletten, CR Bertozzi - Angewandte Chemie International …, 2009 - Wiley Online Library
The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Novel process windows for enabling, accelerating, and uplifting flow chemistry

V Hessel, D Kralisch, N Kockmann, T Noël… - …, 2013 - Wiley Online Library
Abstract Novel Process Windows make use of process conditions that are far from
conventional practices. This involves the use of high temperatures, high pressures, high …