We present WhichTF, a computational method to identify functionally important transcription
factors (TFs) from chromatin accessibility measurements. To rank TFs, WhichTF applies an …

Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing
cholangitis (PSC) are complex disorders, resulting from the interaction of genetic and …

PU. 1 is an E26 transformation-specific family transcription factor that is required for
development of the immune system. PU. 1 functions at both early and late stages of …

Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that
initiate mucosal immune responses through the uptake and transcytosis of luminal antigens …

Activated B cells undergo immunoglobulin class-switch recombination (CSR) and
differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and …

Humoral immunity requires B cells to respond to multiple stimuli, including antigen,
membrane and soluble ligands, and microbial products. Ets family transcription factors …

Natalizumab, an antibody against the α4 subunit of α4 integrins, has been approved for
multiple sclerosis (MS) therapy based on its high efficacy and safety profile. However …

Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor
immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody …

The IRF and Ets families of transcription factors regulate the expression of a range of genes
involved in immune cell development and function. However, the understanding of the …

To date, there is no representative in vitro model for liver sinusoidal endothelial cells
(LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of …